ABATPPT
ABAT Platelet Count and Function Testing SystemsIntroductionThe ABAT platelet...
ABAT Platelet Count and Function Testing SystemsIntroductionThe ABAT platelet count and function testing systems are a range of instruments designed to facilitate the rapid and accurate measurement of platelet parameters. These systems are particularly useful in the diagnosis and monitoring of patients with thrombotic disorders, such as platelet function disorders and aplastic anemia. The following provides a brief overview of the ABAT platelet count and function testing systems:InstrumentationABAT platelet countersThe ABAT platelet counters are benchtop instruments that automate the counting and sizing of platelets. These systems utilize flow cytometry technology to provide accurate enumeration of platelets in whole blood or platelet-rich plasma (PRP). ABAT platelet counters offer a high degree of precision and reproducibility, ensuring reliable results even in the presence of low platelet counts.ABAT platelet function analyzersABAT platelet function analyzers are benchtop instruments that assess platelet function under simulated physiological conditions. These systems evaluate platelet activation, aggregation, and adhesion using various agonists and antagonists. ABAT platelet function analyzers provide information on platelet function disorders, such as Bernard-Soulier syndrome, Glanzmann thrombasthenia, and platelet-type von Willebrand disease.ProcedureABAT platelet countingThe ABAT platelet counting procedure involves the following steps:Collection of a venous blood sample from a fasting patient into an EDTA-containing tubePreparation of a blood smear on a glass slideApplication of the blood smear to the ABAT platelet counterwhich automates the counting and sizing of plateletsAnalysis of the resultswhich provide an accurate enumeration of platelets per microliter of bloodABAT platelet function testingThe ABAT platelet function testing procedure involves the following steps:Collection of a venous blood sample from a fasting patient into a tube containing prostaglandin E1 (PGE1) and apyrase to inhibit platelet activationPreparation of PRP by centrifugation of the blood sample at low speed to pellet the platelets and remove red blood cellsActivation of the PRP with an agonistsuch as thrombin or adrenaline, to stimulate platelet aggregationApplication of the activated PRP to the ABAT platelet function analyzerwhich measures the aggregation response of the plateletsAnalysis of the resultswhich provide information on platelet function disordersClinical UsesABAT platelet countingABAT platelet counting is used for the diagnosis and monitoring of patients with thrombotic disorders, such as:Platelet function disordersPlatelet function disorders result from abnormalities in platelet membrane glycoproteins or signaling pathways that prevent normal platelet aggregation. ABAT platelet counting can identify patients with these disorders by quantifying their platelet countsAplastic anemiaAplastic anemia is a rare disorder characterized by bone marrow failure and severe pancytopenia. ABAT platelet counting can help diagnose this condition by documenting severely reduced platelet counts. It can also be used to monitor response to therapy by serial counting of platelets over timeABAT platelet function testingABAT platelet function testing is used for the diagnosis of patients with inherited or acquired platelet function disorders, such as:Glanzmann thrombastheniaGlanzmann thrombasthenia is a rare inherited disorder characterized by absent or defective fibrinogen receptors on platelets, resulting in severe bleeding tendency. ABAT platelet function testing can identify this condition by demonstrating absent or reduced platelet aggregation in response to agonistsPlatelet-type von Willebrand diseasePlatelet-type von Willebrand disease is an inherited disorder characterized by qualitative or quantitative defects in von Willebrand factor (VWF), leading to impaired platelet adhesion and aggregation. ABAT platelet function testing can identify this condition by documenting reduced platelet aggregation in response to low shear stress conditions that simulate physiological flow conditions
